大学化学 >> 2015, Vol. 30 >> Issue (5): 1-6.doi: 10.3866/pku.DXHX20150501

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化学遗传学简介

高磊2,3, 雷晓光1,2,3   

  1. 1. 北京大学化学与分子工程学院化学生物学系 北京 100871;
    2. 北京协和医学院研究生院 北京 100730;
    3. 北京生命科学研究所 北京 102206
  • 发布日期:2015-10-24
  • 通讯作者: 雷晓光 E-mail:xglei@pku.edu.cn

The Brief Introduction to Chemical Genetics

Gao Lei2,3, Lei Xiaoguang1,2,3   

  1. 1. Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    2. Graduate School of Peking Union Medical College, Beijing 100730, China;
    3. National Institute of Biological Sciences, Beijing (NIBS), Beijing 102206, China
  • Published:2015-10-24

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摘要：

化学遗传学是20世纪90年代开始兴起的交叉学科, 是利用生物活性小分子与蛋白相互作用研究生物学系统功能的一种方法, 是经典遗传学的补充。化学遗传学的历史可以追溯到几百年前。在现代药物靶标的发现上, 化学遗传学起着非常重要的作用。

关键词: 化学遗传学, 经典遗传学, 生物活性分子, 靶标蛋白

Abstract:

Chemical genetics, a new interdiscipline emerging at the nineties of the 20th century, is an approach for studying biological systems by using bioactive small molecules which can interact with their target proteins, and is complement of classic genetics approaches in term of methodology. The history of chemical genetics can be dated back to a few centuries ago and it still plays important role in the target identification of drug discovery.

Key words: Chemical genetics, Classic genetics, Bioactive molecules, Target protein